Nucleic Acid Therapeutics targeting microRNAs
نویسندگان
چکیده
منابع مشابه
Nucleic acid aptamers for targeting of shRNA-based cancer therapeutics
Aptamers are nucleic acid ligands which have been validated to bind to epitopes with a specificity similar to that of monoclonal antibodies. Aptamers have been primarily investigated for their direct function in terms of inhibition of protein targets; however, recent evidence gives reason to actively explore aptamers as targeting moieties for delivery of anticancer therapeutics. Many aptamers h...
متن کاملNucleic acid therapeutics
The discovery of ribozymes by Cech and Altman has fundamentally changed the view of the function of RNA in chemistry, biology, and medicine (1–3). Prior to this discovery, RNA had been viewed as a passive molecule that only carried information or provided structure to RNA-protein complexes. It is now clear that RNA can act as an enzyme and is capable of catalyzing RNA splicing and cleavage, as ...
متن کاملNucleic acid therapeutics
As alterations in gene expression have become a better understood component of normal development and disease pathogenesis, transcription factors and other regulators of gene expression have become an increasingly attractive target for potential therapeutic intervention. Transcription factors are generally nuclear proteins that play a critical role in gene regulation and can exert either a posi...
متن کاملNucleic acid therapeutics
Atherosclerosis arises from an excessive fibroproliferative-inflammatory response to injury of the artery wall and typically evolves over decades (1). Smooth muscle cells play a central role in the development of atherosclerotic lesions. Their ability to migrate from the medial compartment of the artery wall to the intima, where they proliferate, accumulate lipid, and generate extracellular mat...
متن کاملEditorial: Nucleic Acids Research and Nucleic Acid Therapeutics
1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA, 2RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA, 3Departments of Pharmacology & Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA, 4Departments o...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1093/annonc/mdw498